Publications

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plastic-degrading enzymes, ancestral sequence reconstruction, protein landscape analysis, biomathematics, protein characterization, protein engineering, protein evolution Dana Matthews plastic-degrading enzymes, ancestral sequence reconstruction, protein landscape analysis, biomathematics, protein characterization, protein engineering, protein evolution Dana Matthews

Ancestral reconstruction of polyethylene terephthalate degrading cutinases reveals a rugged and unexplored sequence-fitness landscape

Vanessa Vongsouthi, Rosemary Georgelin, Dana S Matthews, Jake Saunders, Brendon M Lee, Jennifer Ton, Adam M Damry, Rebecca L Frkic, Matthew A Spence, Colin J Jackson

Ancestral reconstruction of polyethylene terephthalate degrading cutinases reveals a rugged and unexplored sequence-fitness landscape

Science Advances, 2025

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ancestral sequence reconstruction, machine learning, protein engineering, biomathematics Dana Matthews ancestral sequence reconstruction, machine learning, protein engineering, biomathematics Dana Matthews

Leveraging ancestral sequence reconstruction for protein representation learning

Dana S. Matthews, Matthew A. Spence, Adam C. Mater, James Nichols, Sacha B. Pulsford, Mahakaran Sandhu, Joe A. Kaczmarski, Charlotte M. Miton, Nobuhiko Tokuriki, Colin J. Jackson

Leveraging ancestral sequence reconstruction for protein representation learning

Nature Machine Intelligence, 2024

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consensus design, molecular dynamics, structural biology, protein engineering Dana Matthews consensus design, molecular dynamics, structural biology, protein engineering Dana Matthews

Increasing the Soluble Expression and Whole-Cell Activity of the Plastic-Degrading Enzyme MHETase through Consensus Design

Jake W Saunders, Adam M Damry, Vanessa Vongsouthi, Matthew A Spence, Rebecca L Frkic, Chloe Gomez, Patrick A Yates, Dana S Matthews, Nobuhiko Tokuriki, Malcolm D McLeod and Colin J Jackson*

Increasing the Soluble Expression and Whole-Cell Activity of the Plastic-Degrading Enzyme MHETase through Consensus Design

Biochemistry, 2024

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directed evolution, plastic-degrading enzymes, enzyme screening, protein engineering Dana Matthews directed evolution, plastic-degrading enzymes, enzyme screening, protein engineering Dana Matthews

Improving plastic degrading enzymes via directed evolution

Yvonne Joho, Vanessa Vongsouthi, Chloe Gomez, Joachim S Larsen, Albert Ardevol and Colin J Jackson*

Improving plastic degrading enzymes via directed evolution

Protein Engineering, Design, & Selection, 2024

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