Rendering Proteins Fluorescent Inconspicuously: Genetically Encoded 4‐Cyanotryptophan Conserves Their Structure and Enables the Detection of Ligand Binding Sites

Haocheng Qianzhu, Elwy H Abdelkader, Adarshi P Welegedara, Edan Habel, Nathan Paul, Rebecca L Frkic, Colin J Jackson, Thomas Huber, Gottfried Otting

Rendering Proteins Fluorescent Inconspicuously: Genetically Encoded 4‐Cyanotryptophan Conserves Their Structure and Enables the Detection of Ligand Binding Sites

Angewandte Chemie, 2025

Isolation, identification, and characterisation of the malachite green detoxifying bacterial strain Bacillus pacificus ROC1 and the azoreductase AzrC

Shanza Bibi, Callum W. Breeze, Vusqa Jadoon, Anum Fareed, Alina Syed, Rebecca L. Frkic, Habiba Zaffar, Muhammad Ali, Iftikhar Zeb, Colin J. Jackson, Tatheer Alam Naqvi

Isolation, identification, and characterisation of the malachite green detoxifying bacterial strain Bacillus pacificus ROC1 and the azoreductase AzrC

Scientific Reports, 2025

The ultra-high affinity transport proteins of ubiquitous marine bacteria

Ben E. Clifton, Uria Alcolombri, Gen-Ichiro Uechi, Colin J. Jackson and Paola Laurino

The ultra-high affinity transport proteins of ubiquitous marine bacteria

Nature, 2024

1.3Å Crystal Structure of E.coli Peptidyl–Prolyl Isomerase B with Uniform Substitution of Valine by (2S,3S)-4-Fluorovaline Reveals Structure Conservation and Multiple Staggered Rotamers of CH2F Groups

Rebecca L. Frkic, Yi Jiun Tan, Ansis Maleckis, Nicholas F. Chilton, Gottfried Otting* and Colin J. Jackson*

1.3 Å Crystal Structure of E. coli Peptidyl–Prolyl Isomerase B with Uniform Substitution of Valine by (2S,3S)-4-Fluorovaline Reveals Structure Conservation and Multiple Staggered Rotamers of CH2F Groups

Biochemistry, 2024

Partitioning of an Enzyme‐Polymer Surfactant Nanocomplex into Lipid‐Rich Cellular Compartments Drives In Situ Hydrolysis of Organophosphates

Benjamin M Carter, Graham J Day, William H Zhang, Richard B Sessions, Colin J. Jackson, Adam W Perriman

Partitioning of an Enzyme‐Polymer Surfactant Nanocomplex into Lipid‐Rich Cellular Compartments Drives In Situ Hydrolysis of Organophosphates

Small, 2024

Increasing the Soluble Expression and Whole-Cell Activity of the Plastic-Degrading Enzyme MHETase through Consensus Design

Jake W Saunders, Adam M Damry, Vanessa Vongsouthi, Matthew A Spence, Rebecca L Frkic, Chloe Gomez, Patrick A Yates, Dana S Matthews, Nobuhiko Tokuriki, Malcolm D McLeod and Colin J Jackson*

Increasing the Soluble Expression and Whole-Cell Activity of the Plastic-Degrading Enzyme MHETase through Consensus Design

Biochemistry, 2024

Conformational Preferences of the Non-Canonical Amino Acids (2S,4S)-5-Fluoroleucine, (2S,4R)-5-Fluoroleucine, and 5,5'-Difluoroleucine in a Protein

Rebecca L Frkic, Yi Jiun Tan, Elwy H Abdelkader, Ansis Maleckis, Eliza Tarcoveanu, Christoph Nitsche, Gottfried Otting*, Colin J Jackson*

Conformational Preferences of the Non-Canonical Amino Acids (2S,4S)-5-Fluoroleucine, (2S,4R)-5-Fluoroleucine, and 5,5'-Difluoroleucine in a Protein

Biochemistry, 2024

Identification and Characterization of a Bacterial Periplasmic Solute Binding Protein That Binds l-Amino Acid Amides

Oliver B Smith, Rebecca L Frkic, Marina G Rahman, Colin J Jackson* and Joe A Kaczmarski*

Identification and Characterization of a Bacterial Periplasmic Solute Binding Protein That Binds l-Amino Acid Amides

Biochemistry, 2024

Mononuclear binding and catalytic activity of europium (III) and gadolinium (III) at the active site of the model metalloenzyme phosphotriesterase

Callum W Breeze, Yuji Nakano, Eleanor C Campbell, Rebecca L Frkic, David W Lupton and Colin J Jackson

Mononuclear binding and catalytic activity of europium (III) and gadolinium (III) at the active site of the model metalloenzyme phosphotriesterase

Acta Crystallographica Section D: Structural Biology, 2024

Structural Insights into a Side Chain Cross-Linking Biarylitide P450 from RiPP Biosynthesis

Mathias H. Hansen*, Angus Keto, Maxine Treisman, Vishnu Mini Sasi, Laura Coe, Yongwei Zhao, Leo Padva, Caroline Hess, Victor Leichthammer, Daniel L. Machell, Ralf B. Schittenhelm, Colin J. Jackson, Julien Tailhades, Max Crüsemann, James J. De Voss, Elizabeth H. Krenske and Max J. Cryle*

Structural Insights into a Side Chain Cross-Linking Biarylitide P450 from RiPP Biosynthesis

ACS Catalysis, 2024

Complex Inhibitory Mechanism of Glycomimetics with Heparanase

Cassidy Whitefield, Yen Vo, Brett D Schwartz, Caryn Hepburn, F Hafna Ahmed, Hideki Onagi, Martin G Banwell, Keats Nelms, Lara R Malins and Colin J Jackson

Complex Inhibitory Mechanism of Glycomimetics with Heparanase

Biochemistry, 2023