Ancestral reconstruction of polyethylene terephthalate degrading cutinases reveals a rugged and unexplored sequence-fitness landscape
Vanessa Vongsouthi, Rosemary Georgelin, Dana S Matthews, Jake Saunders, Brendon M Lee, Jennifer Ton, Adam M Damry, Rebecca L Frkic, Matthew A Spence, Colin J Jackson
Science Advances, 2025
Computational and Experimental Exploration of Protein Fitness Landscapes: Navigating Smooth and Rugged Terrains
Mahakaran Sandhu, John Z Chen, Dana S Matthews, Matthew A Spence, Sacha B Pulsford, Barnabas Gall, Joe A Kaczmarski, James Nichols, Nobuhiko Tokuriki, Colin J Jackson
Biochemistry, 2025
Leveraging ancestral sequence reconstruction for protein representation learning
Dana S. Matthews, Matthew A. Spence, Adam C. Mater, James Nichols, Sacha B. Pulsford, Mahakaran Sandhu, Joe A. Kaczmarski, Charlotte M. Miton, Nobuhiko Tokuriki, Colin J. Jackson
Leveraging ancestral sequence reconstruction for protein representation learning
Nature Machine Intelligence, 2024
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